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He required a hospital stay. The following is the structural formula: Clonidine hydrochloride is an odorless, bitter, white, crystalline substance soluble in water and alcohol. If you are being treated for high blood pressure, keep using this medication even if you feel well. Blood pressure was taken every 10 minutes. Naloxone may be a useful adjunct in the treatment of clonidine-induced respiratory depression, hypotension, and/or coma; blood pressure should be monitored since the administration of naloxone has occasionally resulted in paradoxical hypertension. Clonidine, the active ingredient in clonidine hydrochloride extended-release tablet computers, is also authorized as an antihypertensive. Maximum dose 40 mcg/hr as a continuous infusion. Compared to men, women had a lower mean plasma clearance, longer mean plasma half-life, and higher mean peak level of clonidine in both plasma and CSF.In cancer patients who received 14 days of clonidine hydrochloride epidural infusion (rate=30 mcg/hr) plus morphine by patient-controlled analgesia (PCA), steady state clonidine plasma concentrations of 2.2±1.1 and 2.4±1.4 ng/mL were obtained on dosing days 7 and 14, respectively. The plasma elimination half-life was determined to be 22±15 hours following sample collection for 24 hours. Supportive care may include atropine sulfate for bradycardia, intravenous fluids and/or vasopressor agents for hypotension. Each 10 mL vial contains 1 mg (1000 mcg) of clonidine hydrochloride.Each mL of the 500 mcg/mL (0.5 mg/mL) concentration contains 500 mcg of clonidine hydrochloride, USP and 9 mg sodium chloride, USP in water for injection, USP. Clonidine 0.15 or 0.30 mg, was given intravenously every 40 minutes until the diastolic blood pressure was decreased to 120 mm Hg or below. Hydrochloric acid, NF and/or sodium hydroxide, NF may have been added for pH adjustment. This medicine is also available as a transdermal patch worn on the skin.Do not crush, chew, or break an extended-release tablet. However, these studies did not monitor the infants for hemodynamic effects in the days following delivery. The half-life increases up to 41 hours in patients with severe impairment of renal function. The risk of hemodynamic instability, especially hypotension and bradycardia, from epidural clonidine may be unacceptable in these patients. In mice and rats, the oral LD50 of clonidine is 206 and 465 mg/kg, respectively.Familiarization with the continuous epidural infusion device is essential.

Other drugs may interact with clonidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Other side effects include: dizziness. There are no adequate and well-controlled studies in pregnant women during early gestation when organ formation takes place. However, hypotensive episodes occurred throughout the duration of the trial. This allows your blood vessels to relax and your heart to beat more slowly and easily.Clonidine is sometimes given with other medications.Before you take clonidine, tell your doctor if you have heart disease or severe coronary artery disease, a heart rhythm disorder, slow heartbeats, low blood pressure, a history of heart attack or stroke, kidney disease, or if you have ever had an allergic reaction to a Catapres TTS transdermal skin patch.You should not take this medicine if you are allergic to clonidine.To make sure clonidine is safe for you, tell your doctor if you have:low blood pressure, or a history of fainting spells;if you have ever had an allergic reaction to a Catapres TTS skin patch.Older adults may be more sensitive to the effects of this medicine.It is not known whether this medicine will harm an unborn baby. You may report side effects to FDA at 1-800-FDA-1088.PRINCIPAL DISPLAY PANEL – 100 mcg/mL Container LabelPRINCIPAL DISPLAY PANEL – 500 mcg/mL Container LabelWe comply with the HONcode standard for trustworthy health information -

Clonidine lowers blood pressure by decreasing the levels of certain chemicals in your blood. Patients receiving epidural clonidine from a continuous infusion device should be closely monitored for the first few days to assess their response.The 500 mcg/mL (0.5 mg/mL) strength product must be diluted prior to use in 0.9% Sodium Chloride for Injection, USP, to a final concentration of 100 mcg/mL:Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.NDC 68382-602-07, 500 mcg/mL solution in 10 mL vials, packaged individually.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Onset of action is typically within an hour with the effects on blood pressure lasting for up to eight hours. Available for Android and iOS devices. Patients should notify their physician immediately if clonidine administration is inadvertently interrupted for any reason.

Call your doctor for medical advice about side effects. Clonidine has actually been delegated to maternity category C by the FDA. This allows your blood vessels to relax and your heart to beat more slowly and easily. Other use is of unproven safety and is not recommended.

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