Complete blood counts should be monitored weekly in patients who receive linezolid, particularly in those who receive linezolid for longer than two weeks, those with pre-existing myelosuppression, those receiving concomitant drugs that produce bone marrow suppression, or those with a chronic infection who have received previous or concomitant antibiotic therapy. Because similar plasma concentrations of linezolid are achieved regardless of renal function, no dose adjustment is recommended for patients with renal impairment. DOSAGE AND ADMINISTRATION ----- Dosage (by age): Adults and Adolescents 12 Years of Age and Over: • CLARINEX Tablets - one 5 mg tablet once daily or • CLARINEX RediTabs Tablets - one 5 mg tablet once daily or • CLARINEX Oral Solution 2 teaspoonfuls (5 mg in 10 mL) once - … Table 6.
Linezolid has been associated with thrombocytopenia when used in doses up to and including 600 mg every 12 hours for up to 28 days. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. It is not known whether linezolid is excreted in human milk. Commonly used drugs such as phenylpropanolamine and pseudoephedrine have been specifically studied. In Phase 3 comparator-controlled trials, the percentage of adult patients who developed a substantially low platelet count (defined as less than 75% of lower limit of normal and/or baseline) was 2.4% (range among studies: 0.3 to 10.0%) with Linezolid and 1.5% (range among studies: 0.4 to 7.0%) with a comparator. No serotonin syndrome effects (confusion, delirium, restlessness, tremors, blushing, diaphoresis, hyperpyrexia) have been observed in normal subjects receiving linezolid and dextromethorphan.Linezolid is a synthetic antibacterial agent of the oxazolidinone class, which has clinical utility in the treatment of infections caused by aerobic Gram-positive bacteria. U.S. Food and Drug Administration Interactions Avoid Drug Food-What you eat and drink can affect the way your medicines work. Therefore, patients receiving linezolid need to avoid consuming large amounts of foods or beverages with high tyramine content [ The platelet counts for most patients returned to the normal range/baseline during the follow-up period. Pharmacokinetic information generated in pediatric patients with ventriculoperitoneal shunts showed variable cerebrospinal fluid (CSF) linezolid concentrations following single and multiple dosing of linezolid; therapeutic concentrations were not consistently achieved or maintained in the CSF. Table 5. Your prescription is probably not refillable. The cure rates in clinically evaluable patients with ventilator-associated pneumonia were 47% for linezolid-treated patients and 40% for vancomycin-treated patients. The zone size should be determined using a standardized test method The pharmacokinetics of linezolid in patients with severe hepatic impairment have not been evaluated.Linezolid is not an inducer of cytochrome P450 (CYP450) in rats.
Therefore, dose adjustment for geriatric patients is not necessary.The pharmacokinetics of linezolid following a single intravenous dose were investigated in pediatric patients ranging in age from birth through 17 years (including premature and full-term neonates), in healthy adolescent subjects ranging in age from 12 through 17 years, and in pediatric patients ranging in age from 1 week through 12 years. No overall differences in safety or effectiveness were observed between these patients and younger patients, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.In the event of overdosage, supportive care is advised, with maintenance of glomerular filtration. Drug Administration (FDA) 5) Formulary exclusions include but are not limited to the following: a. Linezolid is an oxazolidinone-class antibacterial indicated in adults and children for the treatment of the following infections caused by susceptible Gram-positive bacteria: Nosocomial pneumonia ( One group of patients received Linezolid 600 mg every 12 hours intravenously or orally; the other group received ampicillin/sulbactam 1.5 to 3 g intravenously or amoxicillin/clavulanate 500 to 875 mg every 8 to 12 hours orally. Do not skip doses or stop using linezolid injection without talking to your doctor.
Susceptibility Test Interpretive Criteria for LinezolidStreptococcus pneumoniae
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