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";s:4:"text";s:3714:"Take allopurinol exactly as directed. However, you should not flush this medication down the toilet. The active metabolite of allopurinol is oxypurinol. This section provides information only about this specific pharmacogenomic test.Talk to your health care provider or pharmacist about the results. People with a certain variant in this gene called Toxic epidermal necrolysis is a more serious form of Stevens-Johnson syndrome in which a larger area of the skin or mucous membranes is affected.Most patients treated with allopurinol who develop toxic epidermal necrolysis or These resources may help you understand more about individualized medicine, genomics and drug-gene testing (pharmacogenomics):If you have questions about your test results, ask to speak with your health care provider at your Mayo Clinic care location:Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. They may recommend that you:Only health care professionals, and those you have given permission, may view your genetic test results. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. These are not all of the side effects that may occur. Allopurinol 100-300 mg/day. If you are receiving care at another medical facility, Mayo Clinic recommends you share this information with your other health care providers.Allopurinol is also used to prevent or treat high uric acid levels that may be caused by cancer medicines or for patients with kidney stones that contain calcium.Variants in a gene called HLA-B can affect how you respond to allopurinol. Each variation is given a number. It works by reducing the production of uric acid in the body. HLA-B*5801/Allopurinol Pharmacogenomic Lab Test. Keep taking this medicine (allopurinol tablets) as you have been told by your doctor or other health care provider, even if you feel well. When initiating allopurinol, patients should be closely monitored for hypersensitivity syndrome (eosinophilia, dermatitis, and multi-system failure). Do not take a double dose to make up for a missed one.Allopurinol may cause other side effects. Talk to your doctor about the possible risks of using this medication for your condition.This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.Drink at least eight glasses of water or other fluids each day while taking allopurinol unless directed to do otherwise by your doctor.Take the missed dose as soon as you remember it. Regular blood tests around once a month after starting daily ongoing treatment (e.g. The minimal effective dosage is 100 to 200 mg daily and the maximal recommended dosage is 800 mg daily. Available for Android and iOS devices. Do not stop taking allopurinol without talking to your doctor.Allopurinol is also sometimes used to treat seizures, pain caused by pancreas disease, and certain infections. Continue to take allopurinol even if you feel well. Purpose. help if any of these side effects or any other side effects bother you or do not go away: In some situations, signs or symptoms may be laboratory. Marsha A Raebel PharmD, Pharmacotherapy Research Manager. There are three types of monitoring for people with gout: 1. Start allopurinol at 50- 100mg od and titrate the dose by 50-100mg (the maximum dose is 900mg od) every 4 weeks until target uric acid reached 5. See the FDA's Safe Disposal of Medicines website (It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. 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