Hypoglycemia may be difficult to recognize in these patients. Explain the risks of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development to patients and responsible family members. Sulfonylureas bind to the sulfonylurea receptor in the pancreatic beta-cell plasma membrane, leading to closure of the ATP-sensitive potassium channel, thereby stimulating the release of insulin.The insulinotropic response to a meal is enhanced with Glucotrol XL administration in diabetic patients. Concomitant use of Glucotrol XL with other anti-diabetic medication can increase the risk of hypoglycemia. Multimedia: Slideshows, Images & Quizzes Because of the extensive protein binding of glipizide, dialysis is unlikely to be of benefit.The Chemical Abstracts name of glipizide is 1-cyclohexyl-3-[[p-[2-(5-methylpyrazinecarboxamido)ethyl] phenyl]sulfonyl]urea. Glucotrol XL Oral tablet, extended release drug summary. In a single dose, food effect study in 21 healthy male subjects, the administration of Glucotrol XL immediately before a high fat breakfast resulted in a 40% increase in the glipizide mean CIn a multiple dose study in 26 males with type 2 diabetes mellitus, the pharmacokinetics of glipizide were linear with Glucotrol XL in that the plasma drug concentrations increased proportionately with dose. Therefore, Glucotrol XL should be administered at least 4 hours prior to colesevelam.2.5 mg, blue and imprinted with "Glucotrol XL 2.5" or "GXL 2.5" on one side5 mg, white and imprinted with "Glucotrol XL 5" or "GXL 5" on one side10 mg, white and imprinted with "Glucotrol XL 10" or "GXL 10" on one sideAll sulfonylurea drugs, including Glucotrol XL, are capable of producing severe hypoglycemia Educate patients to recognize and manage hypoglycemia. Steady-state plasma concentrations were achieved by at least the fifth day of dosing with Glucotrol XL in 21 males with type 2 diabetes mellitus and patients younger than 65 years. All sulfonylurea drugs, including Glucotrol XL, are capable of producing severe hypoglycemia [see Adverse Reactions (6)]. Beginning 2 to 3 hours after administration of Glucotrol XL, plasma drug concentrations gradually rise reaching maximum concentrations within 6 to 12 hours after dosing. Endocrinology Drugs 07.01 – Oral diabetic agents – I 151. Glipizide is 98–99% bound to serum proteins, primarily to albumin.The major metabolites of glipizide are products of aromatic hydroxylation and have no hypoglycemic activity. Glipizide is an oral drug that is used for treating patients with type 2 diabetes.It belongs to the sulfonylurea class of drugs which also includes glimepiride (), glyburide (Diabeta, Glynase), tolbutamide and tolazamide. When these medications are discontinued from patients receiving Glucotrol XL, monitor the patient closely for hypoglycemia.Alcohol, beta-blockers, clonidine, and reserpine may lead to either potentiation or weakening of the glucose-lowering effect. Available for Android and iOS devices. A minor metabolite, an acetylamino-ethyl benzene derivative, which accounts for less than 2% of a dose, is reported to have 1/10 to 1/3 as much hypoglycemic activity as the parent compound.Glipizide is eliminated primarily by hepatic biotransformation: less than 10% of a dose is excreted as unchanged drug in urine and feces; approximately 90% of a dose is excreted as biotransformation products in urine (80%) and feces (10%).The mean total body clearance of glipizide was approximately 3 liters per hour after single intravenous doses in patients with type 2 diabetes mellitus. Increased frequency of monitoring may be required when Glucotrol XL is co-administered with these drugs.The signs of hypoglycemia may be reduced or absent in patients taking sympatholytic drugs such as beta-blockers, clonidine, guanethidine, and reserpine. 9 reviews submitted. Glipizide, (Glipizide XL, Glucotrol) is a drug prescribed for the treatment of type 2 diabetes. In a peri- and postnatal study in pregnant rats, there was a reduced number of pups born alive following administration of glipizide from gestation day 15 throughout lactation through weaning at doses ≥5 mg/kg/day (about 2 times the recommended maximum human dose based on body surface area).Breastfed infants of lactating women using Glucotrol XL should be monitored for symptoms of hypoglycemia Monitor breastfed infants for signs of hypoglycemia (e.g., jitters, cyanosis, apnea, hypothermia, excessive sleepiness, poor feeding, seizures).Safety and effectiveness in children have not been established.There were no overall differences in effectiveness or safety between younger and older patients, but greater sensitivity of some individuals cannot be ruled out.