Tissue relaxing drugs are prescribed for bladder disorders as well as hypertension. Other significant associations included male gender, use of rivastigmine, and short axial length; however, these did not retain significance when multivar­iate analysis was performed. Intraoperative floppy iris syndrome associated with tamsulosin. COREG CR is indicated for the treatment of mild-to-severe chronic heart failure of ischemic or cardiomyopathic origin, usually in addition to diuretics, ACE inhibitors, and digitalis, to increase survival and, also, to reduce the risk of hospitalization [see Drug Interactions (7.4), Clinical Studies (14.1)]. Finasteride-associated cataract and intraoperative floppy-iris syndrome. J Korean Ophthalmol Soc. They further emphasized that it is important for ophthalmologists to know whether a patient is at increased risk for IFIS so as to inform the patient preoperatively and to take preventive measures intraoperatively to reduce the potential for serious complications. This irregularity is referred to as Intraoperative Floppy Iris Syndrome (IFIS). Moon HS, et al. Among all factors studied, tamsulosin use was found to convey the highest risk. That’s why potential side effect warnings are lengthy.Ophthalmologists recently discovered that a popularly-prescribed drug to treat Benign Prostatic Hyperplasia (BPH) adversely affects the functionality of the eye’s iris and pupil.This unforeseen side effect causes complications during cataract surgery in a significant number of patients. Among all factors studied, tamsulosin use was found to convey the highest risk.
These drugs are classified as inhibitors rather than blockers. This irregularity is referred to as Intraoperative Floppy Iris Syndrome (IFIS).The drug is Flomax (Tamsulosin), an alpha blocker. Risk Factors for Intraoperative Floppy Iris SyndromeRisk Factors for Intraoperative Floppy Iris Syndrome Intraoperative floppy-iris syndrome and finasteride intake. Other BPH medications with differing active ingredients also adversely affect the iris and pupil but to a lesser degree; Dutasteride (Avodart) and Finasteride (Proscar) for example.It’s not just BPH medications that can cause IFIS. Ford RL, Sallam A, Towler HM . The authors noted that the principal message of this study is that, in addi­tion to the well-known association of α-blockers and IFIS, benzodiazepines, quetiapine, finasteride, and hyperten­sion were identified as significant risk factors.

Keklikci U, Isen K, Unlu K, Celik Y, Karahan M . Ideal cardiovascular health, which is indicative of a healthy lifestyle, lowered the odds for ocular diseases, like age-related macular degeneration, diabetic retinopathy, cataract, and glaucoma. Goyal S, Dalela D, Goyal NK, Chawla S, Dhesi R, Kamboj B Herd MK . Chatziralli IP, Sergentanis TN . Quiz 1: Cardiovascular, Renal, and Endocrine study guide by PrincessLynsie includes 101 questions covering vocabulary, terms and more. Thank you for visiting nature.com. Intraoperative floppy-iris syndrome with doxazosin. González-Martín-Moro J, González-López JJ, Zarallo-Gallardo J, Fernández-Miguel Y . You can also search for this author in The following data were evaluated as possible risk factors: ophthalmological conditions, sociodemographic features, eye colour (routinely collected in the medical records), clinical data (hypertension, diabetes mellitus, renal failure, heart failure) … Systemic a-adrenergic blocking drugs for hypertension, often used in diabetes, are associated with the rare intraoperative floppy iris syndrome. Intraoperative floppy iris syndrome associated with risperidone intake. Asensio-Sánchez VM . The optimum timing of laser treatment in relation to cataract surgery is still debated [9]…. The pupillary dilation must be maintained from cataract removal through insertion of a new intraocular lens. Gupta A, Srinivasan R . 2nd Department of Ophthalmology, Ophthalmiatrion Athinon, Athens, GreeceI P Chatziralli, V Peponis, E Parikakis, A Maniatea, E Patsea & P MitropoulosYou can also search for this author in This problem has occurred in both people who were currently taking tamsulosin and people who had stopped taking tamsulosin. When your eye surgeon is informed about any use of alpha-blockers or inhibitors, complication risk is significantly reduced.Another option is to not initiate (non-emergency) alpha-blocker or inhibitor medications until after cataract surgery. Ugarte M, Leong T, Rassam S, Kon CH . Should we anticipate intraoperative floppy iris syndrome (IFIS) even with very short history of tamsulosin?

This syndrome is associated with medications that are used to treat men with benign prostatic hyperplasia (BPH) and may also be prescribed in women to treat urinary retention or urinary hesitancy. Intraoperative floppy iris syndrome and warfarin: coincidence or side effect? Ipekci T, Akin Y, Hoscan B, Tunckiran A . Intraoperative floppy iris syndrome associated with silodosin. Significant associations were noted for male sex, rivastigmine, and short axial length, which did not reach significance at the multivariate analysis.